Thursday , January 27 2022

Discovery raises doubts about cell surface organization patterns – ScienceDaily



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Like planets, the surface of body cells looks smooth at a distance, but closer to the mountain. Article published Communication biology describes the known effects that are usually interpreted from cell surfaces; i.e. if they lack topographic features.

When Earth is explored from space, its surface looks smooth, but on the zoom we see mountains and valleys. The same goes for cells; without magnification, they look smooth, looking closer to the ridge and the crater.

Researchers at Gothenburg and Uppsala universities in Sweden studied how this variation of cellular topography influences "diffusion" – as molecules move in the cell membrane. Diffusion is being studied to develop patterns for the membrane organization and to increase our understanding of cell component interactions.

The researchers' research was based on their previous discoveries. They showed that none of the 70 types of cells studied had smooth surfaces.

"Today's dominant models for organizing the cell's surrounding plasma membrane are based on two-dimensional interpretation of measurement data. Our study shows that this leads to completely wrong conclusions because the cell surface is three-dimensional," says Ingela Parmryd, Author of the Study, Sahlgrensk Academy Senior Lecturer at Gothenburg University Cell Biology.

In molecular motion studies, cellular topography can cause both marked low membrane movement and deviant motion patterns. This is shown in this study, which is revolutionary in its field.

"The goal of our research is to make a big leap from the current two-dimensional to three-dimensional membrane models. It will change the way we perceive fundamental biological processes, such as cellular signaling, cell and cell contacts, and cell migration. cancer, ”says Ingela Parmryd.

Source of stories:

Materials provided University of Gothenburg. The original was written by Margareta Gustafsson Kubista. Note: Content can be edited for style and length.

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