Saturday , March 6 2021

Parkinson's disease can begin with an add-on



Parkinson's disease has long been considered a brain disease, but several studies point to the role of the digestive system. The study published in the United States on Wednesday is of particular interest to a small body as an unnecessary addition.
The authors of this study, based on the medical data of 1.7 million Swedish, who followed half an hour, found that those with an adjunct to early life had a developmental risk of 19% reduction in Parkinson's disease. This effect seems to be especially true for the Swedish people living in the countryside. They are at risk of being reduced by 25%, while urban areas are not at risk.
For those who developed Parkinson's disease, researchers found that appendectomy (removal of supplementation) was associated with a later three-and-a-half year average, said lead author Viviane Labrie of the Van Andel Research Institute in Michigan during a conference call with the press on Tuesday.
"Our work suggests that the addition could play a role in the onset of Parkinson's disease," she explained, pointing out that this role might not be exclusive.
Parkinson's patients also suffer from gastrointestinal disorders such as constipation for ten years or more before symptoms such as tremors and other mechanical problems occur. This has prompted the scientific community to become interested in the role of the digestive system.
The supplement is a storage site for intestinal bacteria and it seems to play a role in the immune response. It is also the "reservoir" of the main protein of Parkinson's Disease, known as alpha-synuclein, especially in abnormal form.
But this protein is abundant in the appendix for all, sick or not. This suggests to researchers that pathological proteins sometimes manage to escape from the suffix to the brain if it can cause damage.
"This protein does not like to stay in one place," said Viviane Labrie. "She excels from neuron to neuron".
And precisely the nerve, the vagus nerve, connects the digestive tract with the brain. Experiments have shown that protein is able to take this path.
"If it penetrates the brain, it can enter and develop as long as it has a neurotoxic effect that could lead to Parkinson's disease," says a researcher.
The authors of the study warned the press that it was not a recommendation for everyone to remove the attachment. "We are not talking that if you had a removal, you will not have Parkinson's disease," warns Viviane Labrie.
But this work provides another insight into the role of small organs, which one day could lead to therapy to neutralize this reservoir.
There are no causal links at the moment. Like in this type of research, many factors that were not taken into account could explain the difference between those who were destroyed and others.


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