Thursday , January 27 2022

"Brain estrogen-lowering bone production 8 times ↑" … Treatment of osteoporosis "blue light"


Studies have shown that reducing estrogen secretion in the brain hypothalamus can significantly increase healthy bone formation.

The joint authors of the University of California, Los Angeles (UCLA) and San Francisco (UCSF) at the University of California have been published in a recent edition of Nature Communications.

There is currently no treatment for osteoporosis, and it is expected that the result will be the development phase of therapeutic drugs.

According to the Center for Disease Control and Prevention (CDC), one quarter of women in the 65 years and over in the US have osteoporosis.

Researchers have focused on the type of estrogen – a sex hormone that is not known to work in the brain.

In particular, we focused on the function of brain nerve hypothalamus cells with high estrogen sensitivity.

The hypothalamus that connects the nervous system and the endocrine system helps to control body temperature, hunger, sleep and fatigue, and plays an important role in metabolism.

Estrogen in the blood promotes bone growth, but has the opposite function in the brain hypothalamus.

When the estrogen receptor was secreted from the experimental rat core, the rat weighed and became less active.

At first I thought that muscle and fat tissue had increased, but later studies found that weight increased with increasing bone volume.

Some rats have increased bone volume by 800%.

When I used this method in rats with severe osteoporosis, which lost 70% of bone volume, I regained bone density by 50% in a few weeks.

With increased bone density, the bones become very difficult at the same time.

Leading author of the report and Professor of Molecular Pharmacology in Cells Dr. Holling Ghulham says that the current knowledge about bone growth control is not able to explain the findings and suggests that I think I found the way for older women and patients with weak bones.

The team plans to focus on the nucleus of the hypothalamus, which seems to have an effect on bone strength.

Researchers report that these cells can use the energy and resources needed for bone growth to other parts of the body.

Interestingly, this phenomenon only appears in female mice in this experiment.

Inggham has shown that it is unlikely to be discovered, as most neuroscientists have only tested male mice, and if the brain sends out circulating factors that promote bone growth is a real opportunity to develop osteoporosis therapy. He said.

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