Saturday , June 10 2023

The ANSM reports the risk of aortic aneurysm


An increased risk of aneurysm and aortic exclusion after treatment with fluoroquinolones (ciprofloxacin, levofloxacin, moxifloxacin, norfloxacin, flumexin and ofloxacin) was clearly demonstrated. "Thus, for patients with a risk of fracture of aneurysm and aorta, fluoroquinolones should be used only after careful benefit / risk assessment and after taking therapeutic alternatives," says ANSM.

Aorta is the largest body of the body. When it stops, we are talking about aortic aneurysms. Unsupported patients do not have the opportunity to get out.

"Patients should be informed of the risk of aortic aneurysm and fracture and they should be aware that the emergency department should immediately manage sudden, intense abdominal, chest or back pain," the medication agency continues.

Treat bacterial infections

Quinolones and fluoroquinolones are systemically (injectable or oral) or inhaled antibiotics. They are used to treat bacterial infections that may involve a significant prognosis.

Aneurysmic and aortic decomposition factors are family history of aneurysm, anesthesia aneurysm or aortic dissociation, Marfan syndrome, Ehlers-Danlos vascular syndrome, Takayas arteritis, giant cellular arteries (or Horton's disease), Beech disease, high blood pressure and atherosclerosis.

Many involved healthcare professionals

Many healthcare professionals are worried about these new recommendations: family doctors, cardiologists, internists, infectious patients, pulmonologists, ENTs, pediatricians, gastroenterologists, dermatologists, gynecologists, nephrologists, urologists, resuscitators, genitalia, radiologists, doctors, pharmacists, pharmacies and hospitals. pharmacist.

Two studies motivated the decision of the ANSM

In March and July, two studies motivated the ANSM's decision. First published BMJcompared the adverse reactions associated with 360 088 fluoroquinolone recipients (78% ciprofloxacin) compared to those receiving 360 088 amoxicillin recipes. As a result, the aneurysm or aortic decomposition rate with fluoroquinolones increased by 66% over 60 days after antibiotic treatment.

Second, published in 2007 JAMA, also noted that "ciprofloxacin greatly increased the incidence of aortic rupture and rupture in a model of mild and sporadic aortic aneurysmic mice model and cleavage model model". In these mice, ciprofloxacin reduced expression and lysine oxidase activity and increased fiber fragmentation and cellular damage, which may contribute to increased sensitivity to stress-induced aortic destruction. "

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