Thursday , March 4 2021

Strong genetic evidence suggests obesity depression

So far, the largest study found that high correlation between obesity and depression may be genetics and not necessarily metabolic changes.

They found that the genetic predisposition to a higher body mass index is associated with a higher risk of depression and a higher risk for women.Pixabay

That depression and obesity are usually related is no secret. In fact, there are already several studies that confirm that patients with the second usually suffer from the first.

What has not been proven is what first appears: is depression a habit of causing excessive weight gain? Or overweight causing emotional and metabolic reactions that can lead to depression? Are there genes that make someone more exposed to the problem of obesity associated with those who make them more susceptible to depression?

The recent investigation, the most complete one that was carried out in this regard, seems to address this issue. According to a study by Exeter University researchers (England) and the University of South Africa Cancer Research Center, he found preliminary results that A high body mass index (BMI) indicates a high risk of suffering from depression.

"A higher body mass index, with and without adverse metabolic effects, is likely to have a causative role in determining the individual's ability to develop depression," said the results of the study published International Journal of Epidemiology.

In order to make this conclusion, the 19 researchers group analyzed the data available in the United Kingdom, Biobank, a genetic information bank that collects data from about 500,000 people from 37 to 73 years old.

After flooding the first information, researchers found that 340,786 BMI was available on the platform. This large group was surveyed to determine if they have depression or not. So they found it 48,791 participants suffered from depression. The rest – 291,995 people – became a control group.

The researchers analyzed 73 genetic variants which is associated with a high body mass index and a high risk of heart disease, and addresses 14 other variants that are associated with higher body fat but do not increase the risk of heart disease.

The aim of this double analysis was to differentiate the physiological causes of depression, their complete psychological appearance. "Although the first group could be associated with depression using biological or psychological mechanisms, only the second part could have a psychological effect," explains the study by The Guardian.

That is why they discovered that the genetic predisposition to higher body mass is associated with a higher risk of depression and a higher risk for women.

In fact, they found it for each increase of 4.7 points for BMI, the likelihood of depression increased by 18% in general and by 23% among women.

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