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Research reveals genes that provide tropical fever severity

The 20 gene group determines the response of people to the tropical fever, which can be predicted with an accuracy of 80% if the individual is more likely to suffer from the most severe form of the disease, according to Tuesday.

Thus, the authors of the Stanford University study in California (USA) believe that there is an open way to prevent this infection, which affects 200 to 400 million people worldwide each year and causes death of about half a million of them.

The researchers drew attention to the common genetic characteristics of patients who showed tropical fever cases from advanced to severe.

The report published in the scientific journal Cell Reports analyzes data from five previous studies, in which 20 genes stand out in all patients with severe disease.

"We have not compared healthy patients with infected patients, we compared those who had uncomplicated dengue infection with those who developed severe tropical fever," said Purvess Khatri, Professor of Medical and Biomedical Data Science at Stanford Medical School. authors of the study.

In this way, researchers could create a group of genes that let you know if the patient is more susceptible to the disease that spreads through mosquito bites, commonly known as "Aedes aegypti".

To test the validity of the identified genes, the researchers conducted a joint analysis with the Clinical Research Center in Del Valle del Lili, Cali (Colombia).

In the initial stages, 34 participants with tropical fever were evaluated, on which the prognosis of infection development was based on the 20 previously identified genes.

The results coincided fully with an effective diagnosis of what would better develop the infection and who would not.

"Of course, this sample of the population is small, and we want to confirm our data in larger populations," noted Khatri, noting that a new phase of research will be developed in Paraguay.

With a larger population, there is also the opportunity to refine the data that could lead to a decrease in the number of genes, ”said Sirford Einav, professor of medicine and microbiology and immunology at Stanford, and co-author of the study.

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