Thursday , January 27 2022

Intestinal microbes can help prevent the development of milk allergy


Posted on 14/01/2019 17:48:14CET


The intestinal microbial can help prevent the development of cow's milk allergy, suggests research from the University of Chicago, which found that intestinal microbes from healthy human donors transplanted in mice protected milk-bearing animals. suffer from allergic reactions, but there are no gut microbes transplanted from milk allergic children.

The work published by Nature Medicine, co-operating with the National Institute for Allergy and Infectious Diseases, can help researchers develop microbial therapy to prevent or treat food allergies.

Specifically, scientists have previously discovered that infants who are allergic to cow's milk had different gut microbes than non-allergic children. Previous studies also found that some microbes are associated with a lower risk of food allergies, which leads researchers to investigate whether intestinal microbes from infants without milk allergy could be protective.

Researchers transplanted gut microbes from each of the eight child donors into mouse groups grown in sterile medium and sensitive to milk proteins, which means that the animal's immune system produced allergic antibodies to milk.

After being exposed to milk, mice that did not receive microbes or microbes from children who were allergic to milk, developed allergic antibodies and experienced anaphylaxis, a life-threatening allergic reaction. Mice receiving intestinal microbes from non-allergic infants had no response.

The researchers then analyzed the microbes in the stools of children, finding many differences between babies who were allergic to milk and those who did not. Also, mice transplanted with microbes from infants who were allergic also had a microbial family that had previously been identified as protection against food allergies.

Other clinical experiments identified microbial Anaerostipes caccae, which prevented the development of milk allergy by transplanting only to mice. Then, the researchers took cell samples through mouse intestinal coatings, where mice and humans start developing allergies.

They found that mice receiving microbes from non-allergic children expressed different genes compared to those that did not, suggesting that the gut contained in the gut affects the host's immune system.

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