Tuesday , March 9 2021

Gladstone researchers get a new insight into aging in the brain

Protein Klotho has been shown to promote longevity and prevent age-related disturbances. Having more cloths seems to allow longer and healthier living, while the depletion of this molecule accelerates aging and can promote age-related illness. Interestingly, the same structure in the brain contains significantly higher cloth levels than the rest.

This structure is a coriander splege, which includes a complex set of cells that produces cerebrospinal fluid and forms an important barrier between the central nervous system and the blood.

The Gladstone Institute Group, led by MD Lennart Mucke, decided to investigate why the brilliance of coriids contains much more cloth than other cerebellar regions. A new study published in a scientific journal PNAS, they showed that the cloth acts as a goalkeeper that protects the brain from the peripheral immune system.

"In the mouse model, we found that the level of surface area on Kori's planes would naturally decrease with age," said Mucke, a senior researcher and director of the Gladstone Institute for Neurological Diseases. "After that, we interacted with this aging process by reducing the lobe level in this experimental structure, and we found that the depletion of this molecule increases the inflammation of the brain."

Mucke and his team further studied the effects of this phenomenon on other brain regions. They discovered that in mice with a smaller lobe level, the nucleus of a significant memory center correlated with innate immune cells reacted more aggressively when other parts of the body were subjected to infectious immitations of immune problems.

The barrier between the brain and the immune system seems to expand with a low clot level, "said Mika's laboratory scientist Lei Zhu and the first author of the study." Our findings suggest that cloth helps keep this bar closed. When the level of this molecule is reduced by the pressure of the corients, the barrier becomes more porous and allows the immune cells and inflammatory molecules to get easily. "

Such an increased response from innate immune systems may be harmful as they result in certain factors that have been shown to exacerbate brain function.

"The molecular changes we observed in our study suggest that cluster leakage from cori dictance can contribute to the cognitive decline of the elderly through brain inflammation," added Mucke, a neurologist and neuroscientist at San Francisco University. "This could help at least partly explain why we often see cognitive impairment for hospitalized retirees when they have infections, such as pneumonia or urinary tract infections. This complication is especially pronounced in patients with Alzheimer's disease, where inflammation has become a major driver of pathology."

Now that they have shown that clotting out of coriander pressure causes increased inflammation of the brain, Mucke and his team plan their next set of experiments to see if the increasing level of clot in coriander pals can help suppress age-related cognitive decline.



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