Cancer cases could double by 2045 unless warnings were made by the Irish Cancer Society.
They said that immediate action was needed to stop this forecast becoming a reality and that the figures are a "wake-up call."
The company responded to new indicators set out in the National Cancer Register Annual Report.
Averil Power, executive director of the Irish Cancer Society, said the numbers should immediately activate the response.
She said: "Although these forecasts are drastic, they should not become a reality.
"By improving our lifestyle and using free screening, each of us can significantly reduce our risk of developing cancer.
"Four out of ten cancers are preventable. We can all reduce our risk of getting cancer by eating well, realizing and limiting our alcohol consumption.
"Smokers may abandon services such as the Irish Cancer Society's" We Can Abandon "program. The HPV vaccine also gives us an incredible opportunity to virtually eliminate cervical cancer.
"The government must ensure that cancer prevention is fully implemented in the national cancer strategy, which would allow people to make healthy choices while increasing early detection and improved outcomes.
"Eliminating health inequalities is also a priority for the Irish Cancer Society. The less-favored cancer groups are still receiving and dying more than more privileged groups. We will not do this. We will continue to call for better access to all cancer trials, increase the use of screening programs and no obstacles to seeing doctors. .
"Together, these activities can save thousands of lives in the coming years."
Earlier this week, ICS was concerned about the lack of knowledge about lung cancer.
Shocking evidence suggests that three out of five people did not know that Ireland is the largest cancer patient, and only 9% are considered to be the largest murders of women.
A study by Marie Kithin Foundation found that approximately 2,600 people were diagnosed with lung cancer each year.
Foundation Liz Yeates said: "The study showed that there is a lack of awareness of the symptoms of the disease and the shocking attitude that some there in relation to lung cancer.
"We hope we can challenge this attitude."
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