Monday , February 6 2023

To uncover a serious link between complement and Parkinson's disease: an important step forward


Addition affects Parkinson's disease. A summary of all the nestrigons in the world and hypotheses that have begun a major study of almost 1.7 million patients. Published in the journal Science Translation Medicine, the study reveals that patients with a removed supplement have up to 25% less chance of not affecting Parkinson's disease.

Obvious links

Parkinson's disease, named after James Parkinson and described in 1817, is the second most common neurodegenerative disorder after Alzheimer's disease. It's also known as an aging disease, it starts at age 45 and can be reported within the next 30 years. It is a degenerative chronic neurological disease, namely, progressive brain loss, leading to dopamine deficiency in some brain structures. It affects the central nervous system (responsible for progressive disorders: slow movements, tremor, stiffness and cognitive impairment). Its causes are still unknown, although there is significant evidence that the intestines are partially responsible for it.

Indeed, today we know that intestinal Parkinson's disease develops through nerves to return to the brain. The fact is not surprising, because one of the first symptoms of the disease is constipation. The researchers also noticed that protein, alpha-synuclein (a protein directly related to this disease), was in the form of gastrointestinal disorders. Viviane Labrie, the lead author of the study explains that " Although its reputation (annex) is largely "meaningless", the attachment really plays a role in our immune system by regulating the composition of our intestinal bacteria, and now, as it shows us at the beginning of Parkinson's disease"Let's explain here that alpha-synuclein protein builds up in the intestines after an immune response to toxins and bacteria.

However, this is a complex explanation to maintain as the main patient of Parkinson's disease. Due to the slow onset of disease, it takes years to find that dopamine cells disappear to such an extent that trembling or muscular stiffness occurs in the body. However, researchers believe that damage to the brain cells is due to how some alpha-synuclein aggregates and agglomerate. Moreover, it can be noted that for more than a decade this protein accumulation has become increasingly important, leading to an alarming interaction between the brain and the intestines. Of course, there is good evidence, but there is still the fact that people at risk are advancing slowly. It is therefore difficult to obtain and interpret the results of the study for people who do not initially risk.

© youtube / FUTUREMAG – ARTE

Towards a better understanding of the causes?

Recently, this is a study conducted by non-radiologists around the world who have supported two hypotheses about the possible causes of Parkinson's disease. To this end, they associate information about PPMI (Parkinson's progression marker initiatives); It is a clinical observational observation study that covers a wide range of important groups of interest using advanced imaging, biological sampling techniques and clinical and behavioral assessments to identify biomarkers for progression of Parkinson's disease. And the Swedish National Patient Register to look for possible links between neurodegenerative diseases and appendectomies.

A broad study focusing on the observation of almost 1.7 million people suggests that the possibility of non-addict patients with Parkinson's disease decreases by almost 20% and that patients with the annex are intact. Better yet, researchers have made comparison even between patient and residential areas between cities and rural areas, and they indicated that the difference increased to 25% less successful people who no longer had an attachment.

The study does not show in any way that removing the supplement will make you vulnerable to this disease, but it will add a new insight into the causes of Parkinson's disease. in accordance with Vanesa FleuryNeurologist at the University of Geneva Hospital: "This study supports two hypotheses: Parkinson's disease begins at the onset of the digestive tract, and environmental factors such as the effects of pesticides play a role in genetically predisposed individuals in the presentation of pathology."

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