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The intestinal hormone secretion activates energy-consuming brown fats
Researchers have discovered that the long-established secretory of the intestinal hormone has a newly discovered additional function: it activates energy-consuming brown fat, causing a feeling of satiety.
Brown fat helps to lose weight
As brown fat cells consume energy, experts say that they can be the most important weight loss and an important factor in preventing obesity and diabetes. A few weeks ago it was shown that brown flesh tissues activate as much food as it is from the cold. Now one team from the Technical University of Munich (TUM) and a Finnish colleague has explained the physiological mechanism of this activation.
Long-known intestinal hormone
"Surprisingly, we identify the secretary as a key factor," says Professor Martin Klingenspor from the Else Kröner-Fresenius Dietary Medicine Center (EKFZ) TUM, head of the study.
Secretin is a long-known intestinal hormone. Nutrition medicines have so far accepted that this peptide as a messenger essentially serves the functions of the gastrointestinal tract.
How to stimulate water and bicarbonate secretion from the pancreas as soon as the acidified chyme is released from the stomach in the small intestine.
In addition, excretion through the circulatory system is excreted in the brain to promote satiety. As known until recently.
Satits in the brain
A new study published in the Cell magazine, now with molecular biological studies (sequencing of transcripts), reveals that the gene secretory receptor also appeared in brown coarse tissues.
"If we stimulate this receptor in brown fat cells with the secretinium, we could observe immediate activation without jitter-free thermogenesis," prof. Klingenspor
Gray-free thermogenesis is a typical mechanism of brown heat formation, but not only consumes energy.
The study reveals that thermoregulatory without shaking is also a precondition for feeling satiety in the brain.
Pre-made training reviewed
As the letter says, there are three possible channels of communication from brown fat to the brain:
- Temperature increase in the brain
- Nerve compounds from brown fat to the brain or
- especially brown fat messengers, the so-called BAToquin.
Professor Klingenspor believes that heat generation is currently the most likely option:
"Thermogenesis in brown fat causes warming of blood and a slight increase in temperature in the brain, which activates the neurons that transmit saturation."
These conclusions are revised in the earlier assumption that the secretin acts directly on the brain in certain nerve cells, causing a feeling of satiety and reducing the sense of hunger.
"The brown rye tissue is positioned like a relay station," says Professor Klingenspor.
"A good bait could fill you up sooner"
The recently discovered bowel and brain communication chain begins with the secretion of eating, followed by activating brown lipid teratogenicity and warming in the brain, which increases the feeling of satiety.
For example, nutrition-induced thermogenesis in brown fat consumes energy and makes you rich – both important factors in the treatment and prevention of almost the global obesity epidemic.
So the secret would be the right "medicine" in this context? "No," explains Klingenspor. Chronic pancreatic stimulation would be unfavorable.
However, the scientist believes that the way to naturally stimulate the production of secretin by using certain foods is to "quickly fill in a good eatery and reduce the amount of calories".
What nutrients here will be taken into account, research must be continued. (Advertising)
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