Friday , February 26 2021

Stealth-cap technology for light-emitting nanoparticles – ScienceDaily



Helmholtz-Zentrum Dresden-Rossendorf (HZDR) The Helmholtz-Zentrum team of scientists in collaboration with researchers at the University of Monaco, Australia, has significantly increased the stability and biocompatibility of special light portable nanoparticles. The team has developed so-called "upconverting" nanoparticles that not only converts infrared light into UV light, but also water soluble, remain stable in complex body fluids, such as blood serum, and can be used to store medicines. They have developed an instrument that could potentially make the fight against cancer more effective. Researchers recently published their results in a journal Angewandte Chemie.

Nanoparticles are tiny structures, usually less than 100 nanometers, which are approximately 500 to 1000 times smaller than human hair thickness. Such materials are paying more attention to the use of biomedicine. If they are equipped with appropriate properties, they can reach almost all tissues of the human body through the bloodstream – to become perfect body probe.

Within a few years it is known that the distribution of nanoparticles in the body essentially depends on their size and surface properties. Dr. Tanmaya Joshi's HZDR Radiofrequency Cancer Research Institute says: "The transformation of nanomaterials has a strong interest in biomedical imaging." "If stimulated by infrared, they can send out bright blue, green or red signals. If we manage to drive such nano-probes with diseased tissue, this can be particularly useful in cancer diagnostics," team photochemist Dr Massimo Sgarzi added.

However, these light converters show poorly solubility in water or tissue fluids – it must be a function before you can imagine any diagnostic or therapeutic use. For the HZDR team, this was not an obstacle, but rather a challenge: "We used a unique polymer mixture to cover particles," says Dr. Joshi, who joined the HZDR from Monash University in 2017 as Humboldt's colleague. By adding this protective cover, light portable nanoparticles are biologically compatible. Biologist Christopher Zearsler adds: "Uploaders are now water soluble and even contain a neutral surface. Our research shows that this new coating almost completely removes the body's own substance (found in the blood serum) from binding to it. In other words, now it seems that the nanoparticles are worn invisible cemetery. This, in our opinion, will help to avoid their identification and destruction with immune phagocytes. "

Scientists photochemically bind the protective layer to the other in order to keep the new nano-probe in a stable week in a complex biological environment: "We simply irradiated our nanoparticles with UV light, which creates additional links between the molecular components that form the protective sleeve – very similar to embroidering the individual parts of the invisible dress, using light, "explains PhD student Anne Nsubuga. She adds, "This coating is only a few nanometers thick and can even be used to disguise other substances, such as cancer drugs, which can later release the tumor and destroy it."

After this breakthrough, the team now plans to confirm its current results in living organisms: "To achieve this, we must first have strictly regulated and ethically acceptable animal experiments. Only if our secret cap technology works on them without any side effects, their medical potential will be The patient's application has been investigated in detail and can be taken into account, "explains the group leader, caution. Holger Stefan

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